Summer Intern, Stuffer Sequences, Bioinformatics, Vector Biosciences

Duration: 2 Months

Location: 100% Remote

This intern will work on the development of an in silico pipeline to identify AVV stuffer sequences.

The pipeline will follow previously established and newly introduced stuffer sequencing criteria. This will include:

• Conduct a comprehensive literature review to list all the criteria to determine stuff sequences and establish new criteria if needed.

• Find the appropriate genomic dataset from the public repository to run the analyses

• Code and run scripts on the AWS system

• Knowledge of a programming language (R or Python or Perl preferable)

• Opportunity to network and learn from research (next-generation sequencing (NGS) technologies)

• Opportunity to shadow, train, and contribute to NGS data analyses

• A presentation/poster and report output. Depending on the results, the identified stuffer sequences will then be validated by collaborators in vitro, as well as their project scope may expand to other constructs and programs

Intern Job Responsibilities/Deliverables

Month 1: • Overview and training on the AWS system • Review relevant publications on stuffer sequences • Based on the literature search, list the stuffer sequences criteria to computationally predict sites in the human genome • Weekly 1:1 meeting with mentor Gaia Andreoletti

Month 2: • Identify and download the genome reference data to use for the analyses • Write scripts to apply the established stuffer sequences criteria • Identify newly sequences across the genome

Month 3: • Report and presentation of findings at Vector Bioscience meeting

Benefits of the Internship

The student would benefit from a project that has a clear outlined goal and provides the opportunity for training in various cutting-edge NGS methodologies. This role would also provide an opportunity for the student to work cross-functionally with different people within the Vector Bioscience group to obtain results and information. The student would also be required to write a report and present their findings, further developing their skills in those areas.

Intern Qualifications and Skills

• Pursuing a bachelor’s or master’s degree in life sciences   
• Must have an interest in pursuing a career in Life Sciences/Biotech/Pharmaceuticals
• Ability to manage workload effectively including planning, organizing, prioritizing, and meeting deadlines
• Field of interest Bioinformatics, Life science, Bio Engineering, Computer Science.
• Ability to program in R and/or python