Associate I, Technical Development Operations

sgs-job-5962

Scientific
 California
Downstream Process Development
AAV Development
AAV Production
Chromatography
Clarification
Tangential Flow Filtration (TFF)
Sterile Filtration
Column Packing
Depth Filtration
Harvest
Biologics Purification
Single-Use Technologies
Tubing Welders
Process Development
Equipment Operation
Documentation
MS Office
Problem Solving

Contract - 05 months Contract + (Highest Possibilities of extension)

Location : San Francisco, CA 94108 (On-Site) The Associate I, Technical Development Operations will participate in downstream areas of AAV development and production within process development for gene therapy programs and processes. The position supports downstream purification activities, production equipment operations, process development experiments, documentation, and process improvement activities in a collaborative, onsite lab and office environment.

Job Responsibilities:

  • Perform all operations as directed per internal policies and other requirements.
  • Execute experiments for downstream process development activities.
  • Support downstream purification unit operations such as chromatography, clarification, tangential flow filtration, sterile filtration, and column packing.
  • Operate production equipment, including inspection, set up, processing, and cleaning.
  • Establish operating equipment specifications and improve operational techniques.
  • Execute corrective measures addressing any issues in a timely manner.
  • Attend safety meetings and follow all safety procedures as defined, including maintaining a safe work environment for both self and colleagues.
  • Contribute to process improvement plans and help drive them to completion.
  • Conduct operations in a collaborative, team environment with a positive attitude to accomplish goals.
  • Assist with process development experiments following defined experimental plans for non-GMP supply.
  • Prepare and maintain documents for process development and research grade AAV production operations.
  • Maintain digital records of all research production activities using in-house systems and shared digital document repositories.
  • Follow laboratory safety procedures.
  • Perform other duties as assigned.
  • Work onsite in a lab and office-centric position.
  • Be available to work outside of normal business hours and/or overtime as required, including occasional weekend work.

Skills:

  • Understanding of downstream process theory, including Depth Filtration, Harvest, Tangential Flow Filtration, and Column Chromatography.
  • Experience with equipment operation.
  • Strong communication skills with the ability to work effectively both independently and as part of a team.
  • Demonstrated experience maintaining detailed records and assisting with document revisions.
  • Strong computer skills, including MS Office (Word, Excel, PowerPoint).
  • Effective problem-solving skills.
  • Ability to multi-task, be flexible, and thrive in a fast-paced environment.
  • Ability to handle uncertainty and changing priorities.
  • Preferred experience in biologics purification, including protein, enzyme, or AAV purification.
  • Technical understanding of a biotech manufacturing facility.
  • Experience with single-use technologies.
  • Working knowledge of disposable manufacturing methodology, including sterile bags with tubing and tubing welders.

Education/Experience:

  • BS in Life Science or Engineering or equivalent experience.
  • Associate I: 0-2+ years of experience working in a pharmaceutical/biologics lab or manufacturing environment.
  • Demonstrated understanding of downstream process theory and equipment operation.
  • Ability to maintain detailed records and assist in document revisions.
  • Strong computer skills, including MS Office.
  • Ability to work effectively independently and within a team environment.
  • Willingness to work outside normal business hours and/or overtime as required.

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